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Bruce Friedman, a native of Cleveland, Ohio, is a graduate of Williams College and the University of Michigan Medical School. He completed a pathology residency in the Department of Pathology, University of Michigan Medical School, in 1971 and received board certification in both anatomic and clinical pathology that same year. After two years in the Medical Corps of the U.S. Army, he joined the pathology faculty of the University of Michigan.

He is currently an Active Emeritus Professor of Pathology in the Department of Pathology, University of Michigan Medical School. He served on the faculty of the University of Michigan for 33 years, retiring in 2006. His positions there included Director of Pathology Informatics and also Director of Clinical Support Systems for the University of Michigan Health System.

He was a founder of a yearly clinical lab software conference called AIMCL that was offered for 21 years in Ann Arbor under the auspices of the University of Michigan. This was the first national pathology informatics conference. In 2004, the conference was renamed Lab InfoTech Summit and moved to Las Vegas for six years with support from the Pathology Education Consortium (PEC), a non-profit educational foundation that he founded and of which he is the president. In December, 2005, he founded a blog, Lab Soft News, which focuses on clinical lab software and the clinical lab industry. It is considered the first pathology blog in the country.

He is credited with having named the field of pathology informatics in an article published in the American Journal of Clinical Pathology in 1990. He was a founding member, and one of the two founding presidents, of the Association for Pathology Informatics (API). He was named an Honorary Fellow by the API for lifetime achievement in the field at its annual meeting in Vancouver in 2006. He received a lifetime achievement award at the first World Congress on Pathology Informatics in Brisbane, Australia, in 2007. He received the Laboratory Public Service Lifetime Achievement award at the G2 Lab Institute Conference in Washington, D.C. in 2013.

He has served as a consultant and advisor to in-vitro diagnostic and lab software companies as well as hospitals and academic institutions. He served as the co-director of the Pathology Informatics Summit from 2010-2012 conferences. In 2013, he help to develop the LIS Functionality Assessment Toolkit (LIS-FAT) that was published by the Association for Pathology Informatics and is available for download at the API home web page.