LabCorp has licensed an interpretation and reporting system for their CYP450 genetic test results from Signature Genetics. Here is the link to the press release and here is the link to the Signature Genetics home page. Below is an excerpt from the press release:
Increasingly, physicians are using pharmacogenetic tests such as cytochrome P450 (CYP450) to determine if an individual carries genetic variants, or polymorphisms, impacting the safety or effectiveness of many commonly prescribed drugs.... Even with results from the various pharmacogenetic tests for CYP450, however, many physicians still resort to "trial and error" for prescribing and dosing drugs because the genetic information is complex and difficult to interpret. The Signature Genetics interpretation and reporting service is intended to help take the "trial and error" out of selecting the most appropriate drug and establishing the most effective dosage for a given individual....The report details which medications should work most effectively and at what dose, which treatments might cause adverse reactions and/or react with other concurrent treatments, and which types of lifestyle and nutritional changes would have the greatest impact on improving patient health.
A previous post on this blog discussing lab reporting contains a link to a PDF file of an article published in Lab Medicine. In this article, Jules Berman and myself present the concept of the web-based contextualized laboratory report, which is computer-generated and also places the test results from the report into the context or the larger frame of both the patient's medical history and the body of medical knowledge about the patient's disease process accessible via the web. The article goes on to distinguish such a contextualized report from a unique, reimbursable, and individually customized lab medicine consultation in the following way:
We want to emphasize that the contextualized report discussed here should not be confused with the option of providing individualized reimbursable laboratory medicine consultations to clinicians for complex patients. Such consultative reports will be generated on the basis of a request for consultation from the clinician to the pathologist in exactly the same way that all clinicians consult among themselves for complex cases. In contrast, the contextualized report is an automated process that can be generated at a relatively low cost that will serve to enhance the value of all laboratory reports.
The contextualized report, of which the LabCorp/Signature Genetics is one example, represents mass customization for the laboratory world, which is defined in the following way by the Wikipedia:
Mass customization, in marketing, manufacturing, and management, is the use of flexible computer-aided manufacturing systems to produce custom output. Those systems combine the low unit costs of mass production processes with the flexibility of individual customization.
So, in summary, LabCorp/Signature Genetics has announced that they are using information technology to mass customize reports for CYP450 genetic testing because the recommendations will both complex and individualized for each patient. The ability to develop and deploy technology such as this is strategic for that segment of the clinical lab industry involved with sophisticated molecular diagnostics. It is not surprising that such an announcement comes from LabCorp. The only surprising aspect of the announcement is that LabCorp is outsourcing this strategic capability rather than retaining the intellectual property in-house.